3/31/2024 0 Comments Spectra precision terramodel 9.60![]() However, although very high EF can be achieved and several SERS substrates with signal relative standard deviation (RSD) less than 7% were reported 7, 8, 9, commonly used substrates based on metals, either prepared by corrosion or sol-gel methods, show very poor reproducibility with fluctuant EFs that may vary across several orders of magnitudes, which severely hinders the applications of SERS 6, 10, 11. Applicable SERS substrates require both high enhancement factor ( EF) and excellent spatial reproducibility 5, 6. By employing surface plasmon polariton resonance occurring in the vicinity of the metal surface, especially narrow nanogaps between sharp corners and edges of metallic nanostructures, namely “hot spots” 3, 4, 5, the sensitivity of SERS can reach single molecular level 3. Surface enhanced Raman scattering (SERS) provides a powerful non-destructive spectroscopy technique for such identification, which is comparable to single-molecule fluorescence spectroscopy but without suffering from rapid photobleaching 1, 2, 3. ![]() Detection of trace amounts of molecules is a longstanding challenge in catalysis, biology, biomedicine and molecular nanotechnology. ![]()
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